• A non-contact method for determining urine protein, bile urea and fecal occult blood in excreta using fluorescence

    Product development Updated on May 02, 2025

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  • Measurement principle

    This technology integrates a UV light source into the toilet lid to excite specific substances naturally present in urine, such as proteins, uric acid, and urobilin, producing distinct fluorescence signals. Changes in health status can alter the concentration and structure of these substances, leading to variations in their fluorescence characteristics. By capturing and analyzing these signals in real time, the system can provide early indications of kidney dysfunction, metabolic disorders, and liver or bile duct issues, serving as a tool for health monitoring and early disease detection.

    Key features include:

    • Non-contact sensing: No sampling required; detection occurs during normal use.
    • Rapid response: Fluorescence detection completed within seconds.
    • Immediate feedback: Results displayed via an app or onboard screen.
    • Durable design: Built for long-term, everyday household use.

    Future development will integrate AI-driven data analysis for more accurate and personalized health insights.

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    This is our current measurement result.

    The different wavelengths of ultraviolet light can stimulate the fluorescence of protein and urobilin respectively.

    Fluorescence reaction mechanism of urine protein: Protein in urine (especially albumin) will produce fluorescence under UV light. The higher the concentration, the stronger the fluorescence.

    The fluorescence difference is obvious: As can be seen from the figure, the fluorescence intensity and bubble conditions of urine with high protein content are obviously different, which can be used as a basis for judgment.

    Related to renal function: Elevated urine protein (especially urine albumin) is often associated with abnormal glomerular filtration function and is an early indicator of chronic kidney disease.

    Posted on April 28, 2025

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    This is our current measurement result.

    This is the result of the measurement using a spectrometer. When the human body is very tired, kidney and liver related metabolites accumulate in the urine, and the metabolites stimulate fluorescence.

    Posted on April 29, 2025

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    This is our current measurement result.

    Urine fluorescence in breast cancer patients

    Nitrogen-containing metabolites such as polyamines: They are weakly fluorescent and may produce yellow-green or orange-red fluorescence when excited by UV light. In addition, urobilinogens fluoresce green-yellow to red when excited at 365–400 nm, which may correspond to the region of fluorescence you see.

    Supporting Literature and Case Studies

    Urinary Metabolites for Breast Cancer Detection: Specific metabolites were found to be elevated in the urine of breast cancer patients and could be identified by LC-MS or spectral analysis.

    Posted on May 2, 2025

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    Bilirubin in urine

    The different wavelengths of ultraviolet light can stimulate the fluorescence of protein and urobilin respectively.

    Urobilinogen/bilirubin derivatives in urineUsually related to liver function, the concentration of bilirubin increases when bilirubin metabolism is abnormal. When urine is irradiated with a specific wavelength, blue to blue-green fluorescence is produced.

    Normal bilirubin is excreted into bile after being conjugated in the liver. However, abnormal liver function may cause urobilinogen and bilirubin derivatives to be retained or excreted into the urine, producing a distinct blue-green fluorescence.

    It is recommended to stop drinking, replenish water and nutrition, and usually a decrease in fluorescence intensity can be seen within a few days.

    Posted on May 12, 2025

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    Installation Location

    The toilet lid, when closed, functions like a dark chamber, effectively reducing interference from external light sources.
    Multiple light sources and fluorescence detection modules (such as spectrometers or photodetectors) can be installed in the toilet. When the lid is closed, ambient light is significantly minimized, thereby improving detection accuracy. Possible installation positions are shown in positions A or B in the diagram.

    The UV excitation light sources must be activated sequentially. When driven in sequence, each source can detect fluorescence under different UV wavelengths. This method enables in-home detection of excreta.

    Published on May 8, 2025

  • Related Literature

    Cancer detection by native fluorescence of urine

    https://pubmed.ncbi.nlm.nih.gov/21054119/